ZHU xiaoyan
1. Personal Data:
ZHU Xiaoyan, female, born in Inner Mongolia China. Ph. D., Associate Professor, Doctoral supervisor.
Memberships and social service:
Member of Anatomy and Histoembryology of Animals Branch of Chinese Association of Animal Science and Veterinary Medicine, Member of the Chinese Neuroscience Society, Member of the American Society for Neuroscience, Member of the American Society of Animal Science, Member of the Shaanxi Natural Medicine Society, Professional Committee Member of Biochemical and Molecular Pharmacology of Shaanxi Pharmacological.
Communication evaluation expert of life Science Department of National Natural Science Foundation of China, Communication evaluation expert of academic dissertations of Ministry of Education. Reviewer for Journal of Neuroinflammation , Journal of Neurochemistry , Frontiers in Pharmacology , etc.
2. Education and Professional Positions:
(1) Education:
2013 -2017 PhD in Neurobiology, U1195 Inserm and University Paris-Sud and University Paris-Saclay, France
2009 - 2012 Master in Clinical Veterinary Medicine, Jilin University, China
2005 - 2009 Bachelor in Veterinary Medicine, Inner Mongolia Minzu University, China
(2) Professional Positions:
2021 - present Associate Professor, College of Veterinary Medicine, Northwest A&F University, China
2017 - 2020 Lecturer, College of Veterinary Medicine, Northwest A&F University, China
3. Research Interests and Teaching Courses:
(1) Research Interests:
Neuroimmunoendocrinology, engaged in the neurotoxicology and neuroprotection of animals.
(2) Teaching Courses:
Undergraduate courses: Anatomy and Histoembryology of Animals, Neurobiology
Graduate courses: Special topics in Neurobiology, Animal neuroscience
4. Grants (China):
Introduction of Foreign Doctoral Project of Shaanxi province,
Key Research and Development Project of Shaanxi, China, 2021NY-021
Technological Innovation Guidance Project of Shaanxi, China, 2020QFY10-04
Key Research and Development Project of Shaanxi, China, 2019ZDXM3-02
National Natural Science Foundation of China, 31802154
China Postdoctoral Science Foundation Funded Project, 2019T120957
Natural Science Foundation of Shaanxi, China, 2018JM3041
China Postdoctoral Science Foundation Funded Project, 2018M631210
Doctoral Scientific Research Fund of Northwest A&F University,2452017210
5. Representative academic achievements:
(1) Publications:
Penghao Sun#, Mengli Wang#, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu*, XuejunChai*, Shanting Zhao*. Eucommiae cortex polysaccharides mitigate obesogenic diet-induced cognitive and social dysfunction via modulation of gut microbiota and tryptophan metabolism. Theranostics . 2022; 12(8): 3637-3655. (Corresponding author)
Yuhuan Xue†, Xiaoyan Zhu†, Wenyong Yan, Zhihan Zhang, Enhui Cui, Yongji Wu, Cixia Li, Jiarong Pan, Qijiang Yan, Xuejun Chai* and Shanting Zhao*. Dietary supplementation with Acer truncatum oil promotes remyelination in a mouse model of multiple sclerosis. Frontiers in Neuroscience . 2022 May 02. doi: 10.3389/fnins.2022.860280. (Co-first author)
Jian Huang, Xuejun Chai, Yongji Wu, Yan Hou, Cixia Li, Yuhuan Xue, Jiarong Pan, Yongkang Zhao, Aimin Su, Xiaoyan Zhu*, Shanting Zhao*. β-Hydroxybutyric acid attenuates heat stress-induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF-κB pathways in the hippocampus. FASEB Journal . 2022 Apr;36(4):e22264. doi: 10.1096.202101469RR. (Corresponding author)
Cixia Li#, Xuejun Chai#, Jiarong Pan, Jian Huang, Yongji Wu, Yuhuan Xue, Wentai Zhou, Jiping Yang, Xiaoyan Zhu*, Shanting Zhao*. β-Hydroxybutyrate Alleviates Low Glucose-Induced Apoptosis via Modulation of ROS-Mediated p38 MAPK Signaling. Journal of Molecular Neuroscience . 2022 May;72(5):923-938. (Corresponding author)
Xiaoyan Zhu*, Jian Huang, Yongji Wu, Shanting Zhao, Xuejun Chai*. Effect of Heat Stress on Hippocampal Neurogenesis: Insights into the Cellular and Molecular Basis of Neuroinflammation-Induced Deficits. Cellular And Molecular Neurobiology . 2021 Nov 12. doi: 10.1007/s10571-021-01165-5.
Xiaoyan Zhu*, Yongji Wu, Jiarong Pan, Cixia Li, Jian Huang, Enhui Cui, Ziluo Chen, Wentai Zhou, Xuejun Chai*, Shanting Zhao*. Neuroinflammation induction and alteration of hippocampal neurogenesis in mice following developmental exposure to gossypol. International Journal of Neuropsychopharmacology . 2021, 24(5): 419–433.
Magalie Fréchou2, Xiaoyan Zhu2, Narender Kumarc, Regine Sitruk-Ware, Michael Schumacher, Claudia Mattern, Rachida Guennoun*. Sex differences in the cerebroprotection by Nestorone intranasal delivery following stroke in mice. Neuropharmacology . 2021 Oct 15;198:108760. doi: 10.1016/j.neuropharm.2021.108760. (Co-first author)
Xiaoyan Zhu*, Yongji Wu, Cixia Li, Wenyong Yan, Jiarong Pan, Shuzhong Wang, Shanting Zhao*. Prenatal exposure to gossypol impairs corticogenesis of mouse. Frontiers in Neuroscience , 2020,14:318. doi: 10.3389/fnins.2020.00318.
Shuzhong Wang, Xuzhao Li, Qianru Zhang, Xuejun Chai, YiWang, Eckart Förster, Xiaoyan Zhu*, Shanting Zhao*. Nyap1 regulates multipolar-bipolar transition and morphology of migrating neurons by Fyn phosphorylation during corticogenesis. Cerebral Cortex , 2020, 30(3):929-941. (Corresponding author)
Mengmeng Liu, Mingrui Xu, Mengli Wang, Shuzhong Wang, Kaikai Li, Xinran Cheng, Yongji Wu, Yi Wang, Xiaoyan Zhu*, Shanting Zhao*. Maternal exposure to swainsonine impaired the early postnatal development of mouse dentate gyrus of offspring. Neurochemistry International , 2019, 129:104511. (Corresponding author)
Xiaoyan Zhu, Magalie Fréchou, Michael Schumacher, Rachida Guennoun*. Cerebroprotection by progesterone following ischemic stroke: Multiple effects and role of the neural progesterone receptors. Journal of Steroid Biochemistry and Molecular Biology , 2019, 185:90-102.
Jinfeng Zhang1, Xiaoyan Zhu1, Yezi Kong, Yan Huang, Xukun Dang, Linshan Mei, Baoyu Zhao, Qing Lin*, Jianguo Wang*. Strontium stimulates alkaline phosphatase and bone morphogenetic protein-4 expression in rat chondrocytes cultured in vitro. Journal of Trace Elements in Medicine and Biology , 2019, 55:15-19. (Co-first author)
Xiaoyan Zhu, Yezi Kong, Yan Huang, Baoyu Zhao, Jianguo Wang*. Influence of strontium on vascular endothelial growth factor and fibroblast growth factor 2 expression in rat chondrocytes cultured in vitro. Biological Trace Element Research , 2018, 190 (2): 466-471.
Mengmeng Liu, Guohong Li, Mengli Wang, Xinran Cheng, Yinxue Huang, Mingrui Xu, Kaikai Li, Jiong Chen, Xiaoyan Zhu*, Shanting Zhao*. Further studies about coactosin-like protein-1 affecting the migration of mouse neocortical neurons. Journal of Molecular Histology , 2018, 49(5):519-530. (Corresponding author)
Xiaoyan Zhu, Magalie Fréchou, Philippe Liere, Shaodong Zhang, Antoine Pianos, Neïke Fernandez, Christian Denier, Claudia Mattern, Michael Schumacher*, and Rachida Guennoun*. A role of endogenous progesterone in stroke cerebroprotection revealed by the neural-specific deletion of its intracellular receptors. The Journal of Neuroscience , 2017, 37(45):10998-11020.
Xiaoyan Zhu, Jianguo Wang, Guanghong Xie, Haihua Feng, Xiaobing Li, Lei Liu, Xiaoxu Wang, Dongna Li, Zhaoxi Liu, Jian Qian, Zhe Wang, Guowen Liu*. Effect of copper on the expression of TGF-β in incubated chondrocytes of newborn pigs. Biological Trace Element Research , 2011, 143:1461-1469.
Jianguo Wang*, Xiaoyan Zhu, Guanghui She, Yezi Kong, Yazhou Guo, Zhe Wang, Guowen Liu, Baoyu Zhao*. Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders. BMC Veterinary Research . 2018, 14(1):236. (Co-first author)
Wenyan Yang, Jianguo Wang, Xiaoyan Zhu, Yunhang Gao, Zhaoxi Liu, Liang Zhang, Hui Chen, Xiaoxia Shi, Lianyu Yang, Guowen Liu*. High lever copper promote ghrelin gene expression in the fundic gland of growing pigs. Biological Trace Element Research . 2012;150:154-157. (Co-first author)
Jianguo Wang, Xiaoyan Zhu, Chengzhen Chen, Xiaobing Li, Yan Gao, Peng Li, Yi Zhang, Miao Long, Zhe Wang*, Guowen Liu*. Effect of insulin-like growth factor-1 (IGF-1) on the gluconeogenesis in calf hepatocytes cultured in vitro. Molecular and Cellular Biochemistry , 2012, 362:87-91. (Co-first author)
Jianguo Wang, Xiaoyan Zhu, Guanghong Xie, Yonghong Zhang, Zhaoxi Liu, Liang Zhang, Chenxu Zhao, Wentao Yang, Xiaoxia Shi, Zhe Wang*, Guowen Liu*. Effect of copper on the expression of IGF-1 from chondrocytes in newborn piglets in vitro. Biological Trace Element Research . 2012, 148:178-181. (Co-first author)
Xue Yuan, Jianguo Wang, Xiaoyan Zhu, Zhigang Zhang, Yongxing Ai, Guoquan Sun, Zhe Wang*, Guowen Liu*. Effect of copper on levels of collagen and alkaline phosphatase activity from chondrocytes in newborn piglets in vitro. Biological Trace Element Research . 2011,144:597-605. ((Co-first author)
Jianguo Wang, Xiaoyan Zhu, Xiaobing Li, Wei Wang, Xiaoxu Wang, Lei Liu, Qinghua Deng, Ge Bai, Jianfa Wang, Haihua Feng, Zhe Wang*, Guowen Liu*. Effects of copper on proliferation and autocrine secretion of insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in chondrocytes from newborn pigs in vitro. Biological Trace Element Research , 2011, 144:588-596. (Co-first author)
(2) Book chapters:
Schumacher, M., Zhu, X., Guennoun, R. Progesterone: Synthesis, Metabolism, Mechanism of Action, and Effects in the Nervous System. In: Pfaff, D.W and Joëls, M. (editors-in-chief), Hormones, Brain, and Behavior 3rd edition, Vol 3. Oxford: Academic Press; 2017. pp. 215-244.
6. Contact Information:
Post address: College of Veterinary Medicine, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi, 712100, China
E-mail: xyzhu0922@nwsuaf.edu.cn, xyzhu0922@163.com