NAN yuchen
NAN Yuchen
Ph.D., Associate Professor.
Contact information
Address: College of Veterinary Medicine, Northwest A&F University
No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Email: nanyuchen2015@nwafu.edu.cn,
1. Education and Work Experience
08.2015 – present, Associate Professor, College of Veterinary Medicine, Northwest A&F University, Yangling, China;
08.2014 – 07.2015, Postdoctoral training, College of Veterinary Medicine, University of Maryland College Park, the United States;
09.2009 – 07.2014, Ph.D., College of Veterinary Medicine, University of Maryland College Park, the United States;
09.2007 – 07.2009, Master, Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, China;
09.2003 – 07.2007, Bachelor, Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University
2. Research and Teaching
Research interests:
Prevention and control of ASFV, PRRSV and HEV.
Identification of prion-like protein from virus
Teaching:
Veterinary Immunology, Molecular Virology for bachelor students.
3. Memberships and Academic Services
Member of the American Society of Microbiology
Member of the American Society of Virology
4. Publications
2021
[1] Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou*, Yuchen Nan * and Chunyan Wu*; A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets, Veterinary Research,
[2] Chengbo Zhu, Jingrui Li, Chaonan Tian, Mengmeng Qin, Zhenni Wang, Bingjun Shi, Guanggang Qu*, Chunyan Wu* and Yuchen Nan * ; Proteomic Analysis of ISGylation in Immortalized Porcine Alveolar Macrophage Cell Lines Induced by Type I Interferon, Vaccines,
[3] Xiaohui Ju, Fang Li, Jingrui Li, Chunyan Wu, Guangtao Xiang Xiaomin Zhao, Yuchen Nan* , Dongming Zhao * and Qiang Ding * ; Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction, Veterinary Microbiology,
[4] Zhaobin Zhou, Yinqian Xie, Chunyan Wu*, and Yuchen Nan* ; The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral Capsid, Frontiers in Microbiology,
[5] Jie Wang, Yajing Wang, Bing Liu, Yunwei He, Zhiwei Li, Qin Zhao, Yuchen Nan* and Chunyan Wu; Porcine epidemic diarrhea Virus envelope protein blocks SLA-DR expression in barrow-derived dendritic cells by inhibiting promoters activation, Frontiers in Immunology,
2020
[1] Chunyan Wu, Bingjun Shi, Di Yang, Kun Zhang, Jie Li, Jie Wang, Hongliang Liu, Qin Zhao, En-Min Zhou* and Yuchen Nan* ; Porcine Reproductive and Respiratory Syndrome Virus promotes SLA-DR-mediated antigen presentation of non-structure proteins to evoke a non-neutralizing antibody response in vivo , Journal of Virology
[2] Yafei Li, Junhui Li, Sun He, Wei Zhang, Jian Cao, Xiaomei Pan, Huifen Tang, En-Min Zhou *，Chunyan Wu* and Yuchen Nan* ; Interferon Inducing Porcine Reproductive and Respiratory Syndrome Virus Vaccine Candidate Protected Piglets from HP-PRRSV Challenge and Evoke a Higher Level of Neutralizing Antibodies Response, Vaccines,
[3] Xiaohui Ju, Guangtao Xiang, Mingli Gong, Rui Yang, Jierui Qin, Yafei Li, Yuchen Nan, Yonglin Yang, Qiangfeng Cliff Zhang, Qiang Ding; Identification of Functional cis-acting RNA Elements in Hepatitis E Virus Genome Required for Virus Replication, PLoS pathogen,
[4] Chunyan Wu, Guoqian Gu, Tianshu Zhai, Yajing Wang, Yongling Yang, Yafei Lia, Xu Zheng, Qin Zhao, En-Min Zhou∗ and Yuchen Nan∗; Broad neutralization activity against both PRRSV-1 and PRRSV-2 and enhancement of cell mediated immunity against PRRSV by a novel IgM monoclonal antibody, Antiviral Research,
[5] Yan Wang, Rui Li, Songlin Qiao, Jiaxi Wang, Hongliang Liu, Zhijun Li, Hongfang Ma, Lei Yang, Haiyu Ruan, Maoyang Weng, Julian A Hiscox, James P Stewart, Yuchen Nan∗ , Gaiping Zhang∗, En-Min Zhou∗; Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication, Frontiers in Microbiology
2019
[1] Lizhen Wang, Lu Zhang, Baichen Huang, Kuokuo Li, Gaopeng Hou, Qin Zhao, Chunyan Wu, Yuchen Nan, Taofeng Du, Yang Mu, Jixun Lan, Hongying Chen and En-Min Zhou*; A Nanobody Targeting Viral Non-Structural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication, Journal of Virology;
[2] Tianshu Zhai, Chunyan Wu, Nana Wang, Binjun Shi, Jie Li, Rui Chen, Jianhui Dong, Yiying Zhanga, En-Min Zhou⁎ and Yuchen Nan* ; Development of a monoclonal antibody against swine leukocyte antigen (SLA)-DR α chain and evaluation of SLA-DR expression in bone marrow derived dendritic cells after PRRSV infection, Veterinary Immunology and Immunopathology;
[3] Pengfei Li, Zixiang Zhu, Xiangle Zhang, Wen Dang, Linlin Li, Xiaoli Du, Miaotao Zhang, Chunyan Wu, Qinghong Xue, Xiangtao Liu, Haixue Zheng* and and Yuchen Nan* ; The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway, Viruses;
[4] Gaopeng Hou, Biyun Xue, Liangliang Li, Yuchen Nan , Lu Zhang, Kuokuo Li, Qin Zhao, Julian Hiscox, James Stewart, Chunyan Wu*, Jingfei Wang* and En-Min Zhou*; Direct interaction between CD163 N-terminal domain and MYH9 C-terminal domain contributes to porcine reproductive and respiratory syndrome virus internalization by permissive cells, Frontiers in Microbiology;
[5] Donglei Sun, Peng Sun, Hongmei Li, Mingshun Zhang, Gongguan Liu, Ashley B. Strickland, Yanli Chen, Yong Fu, Juan Xu, Mohammed Yosri, Yuchen Nan, Hong Zhou, Xiquan Zhang and Meiqing Shi*; Fungal dissemination is limited by liver macrophage filtration of the blood, Nature Communication;
[6] Biyun Xue, Gaopeng Hou, Guixi Zhang, Jingjing Huang, Liangliang Li, Yuchen Nan , Yang Mu, Lizhen Wang, Lu Zhang, Ximeng Han, Xiaolei Ren, Qin Zhao, Chunyan Wu * , Jingfei Wang * and En-Min Zhou * ; MYH9 Aggregation Induced by Direct Interaction with PRRSV GP5 Ectodomain Facilitates Viral Internalization by Permissive Cells, Frontiers in Microbiology;
[7] Huixia Li, Mengnan Fan, Baoyuan Liu, Pinpin Ji, Yiyang Chen, Beibei Zhang, Yani Sun, Baicheng Huang, Yuchen Nan , Zhenzhao Sun, James P Stewart, Julian A Hiscox, Qin Zhao * and En-Min Zhou * ; Chicken Organic Anion-Transporting Polypeptide 1A2, a Novel Avian Hepatitis E Virus (HEV) ORF2-Interacting Protein, Is Involved in Avian HEV Infection, Journal of Virology;
2018
[1] Yuchen Nan, Chunyan Wu, Qin Zhao, Yani Sun, Yan-Jin Zhang and En-Min Zhou * ; Vaccine development against zoonotic hepatitis E virus: unmet needs for public health, Frontiers in Microbiology;
[2] Yuchen Nan* ; and Yan-Jin Zhang * ; Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds, Frontiers in Microbiology;
[3] Yuchen Nan* ; Chunyan Wu * ; and Yan-Jin Zhang * ; Interferon Independent Non‐Canonical STAT Activation and Virus Induced Inflammation, Viruses ;
[4] Yiyang Chen, Baoyuan Liu, Yani Sun, Huixia Li,Taofeng Du, Yuchen Nan, Julian A. Hiscox, En-Min Zhou, Qin Zhao; Characterization of Three Novel Linear Neutralizing B-Cell Epitopes in the Capsid Protein of Swine Hepatitis E Virus, Journal of Virology;
[5] Liangliang Li; Biyun Xu; Weiyao Sun; Guoqian Gu; Gaopeng Hou; Lu Zhang; Chunyan Wu; Qin Zhao; Yanjin Zhang; Gaiping Zhang; Julian A. Hiscox; Yuchen Nan* and En-Min Zhou * ; Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5, Antiviral Research ;
[6] Liping Yang, Rong Wang, Shixing Yang, Zexu Ma, Shaoli Lin, Yuchen Nan , Qisheng Li Qiyi Tang, Yan-Jin Zhang*; Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus, Journal of Virology;
2017
[1] Taofeng Du#, Yuchen Nan # , Shuqi Xiao, Qin Zhao and En-Min Zhou*; Antiviral Strategies against PRRSV Infection, Trends in Microbiology ;
[2] Yuchen Nan , Chunyan Wu, Guoqian Gu, Weirao Sun and En-Min Zhou*; Improved Vaccine against PRRSV: Current progress and future perspective, Frontiers in Microbiology
[3] Liping Yang, Rong Wang, Zexu Ma, Yueqiang Xiao, Yuchen Nan , Yu Wang, Shaoli Lin and Yan-Jin Zhang*. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Nsp5 by Inducing STAT3 Degradation, Journal of Virology
[6]Yuchen Nan, Chunyan Wu, Qin Zhao and En-Min Zhou*； Zoonotic Hepatitis E Virus: An Ignored Risk for Public Health; Frontiers in Microbiology;
[7]Yuchen Nan*, Chunyan Wu* and Yan-Jin Zhang*；Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism; Frontiers in Immunology;
2016
[1] Yuchen Nan * and Yan-Jin Zhang*; Molecular Biology and Infection of Hepatitis E Virus, Frontiers in Microbiology;
[2] Zexu Ma , Ying Yu, Yueqiang Xiao, Tanja Opriessnig, Rong Wang, Liping Yang, Yuchen Nan , Siba K. Samal, Patrick Gerard Halbur and Yan-Jin Zhang, Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain, Scientific Reports , 2016, 6:36312；
2015
[1] Yuchen Nan ，Ma, Zexu，Kannan, Harilakshmi，Stein, David A，Iversen, Patrick ，Meng, Xiang-Jin，Zhang, Yan-Jin, Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers.， Antiviral Research ;
[2] New insights into virus–cell interactions during HEV infection: The double roles of HEV in IFNs induction. Chunyan Wu, Yuchen Nan and Yan-Jin Zhang; Future Virology;
2014
[1] Yuchen Nan , Guoxin Nan and Yan-Jin Zhang: Interferon Induction and Antagonism by RNA Viral Pathogens. Viruses ;
[2] Yuchen Nan , Ying Yu, Zexu Ma, Sunil Khattar, Brenda Fredericksen, and Yan-Jin Zhang: Hepatitis E Virus Inhibits Type I Interferon Induction by ORF1 Product. Journal of Virology
[3] Yuchen Nan , Zexu Ma, Rong Wang, Ying Yu, and Yan-Jin Zhang: Enhancement of interferon induction by ORF3 product of hepatitis E virus. Journal of Virology
2013
[1] Rong Wang, Yueqiang Xiao, Tanja Opriessnig, Yi Ding, Ying Yu, Yuchen Nan , Zexu Ma, Patrick G Halbur, Yan-Jin Zhang: Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain. Vaccine
[2] Rong Wang, Yuchen Nan , Ying Yu, Zengqi Yang, and Yan-Jin Zhang: Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus. Veterinary Microbiology
[3] Rong Wang, Yuchen Nan , Ying Yu, and Yan-Jin Zhang: Porcine Reproductive and Respiratory Syndrome Virus Nsp1β Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin-α1 Degradation, Journal of Virology;
2012
[1] Yuchen Nan , Rong Wang, Meiyan Shen, Kay S. Faaberg, Siba K. Samal, and Yan-Jin Zhang: Induction of Type I Interferons by a Novel Porcine Reproductive and Respiratory Syndrome Virus Isolate. Virology 2012; 432:261-270；
[2] Yanjin Zhang, Deendayal Patel, Yuchen Nan and Sumin Fan: Inhibition of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. International Journal of Molecular Medicine, 2012, 30:S33-S33;
[3] Krit Ritthipichai, Yuchen Nan , Ioannis Bossis, Yan-Jin Zhang: Viral FLICE Inhibitory Protein of Rhesus Monkey Rhadinovirus Inhibits Apoptosis by Enhancing Autophagosome Formation. PLoS ONE 2012; 7(6): e39438. doi:10.1371/journal.pone.0039438；
2011
[1] Yan-Jin Zhang, Deendayal Patel, Yuchen Nan , and Sumin Fan: Inhibition of Early Lytic Genes of Kaposi’s Sarcoma-Associated Herpesvirus by Antiviral Morpholino Oligomers Leads to Engraftment Suppression of Primary Effusion Lymphoma in SCID Mice. Antiviral Therapy 2011; 16:657-66；
2010
[1] Deendayal Pate#, Yuchen Nan #, Meiyan Shen, Krit Ritthipichai, Xiaoping Zhu, and Yan-Jin Zhang: Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I IFN Signaling by Blocking STAT1/STAT2 Nuclear Translocation, Journal of Virology ;
6. Projects and Funding
[1] General Project, No. 32170165, National Natural Science Foundation of China (NSFC), 600,000 RMB Yuan, 2022 - 2025 grant holder.
[2] Development of ASFV subunit vaccine. Industrial service agreement, 1.5 million RMB Yuan, 2021 – 2025, lead researcher.
[3] Development of ASFV mRNA vaccine. Industrial service agreement, 3 million RMB Yuan, 2021 – 2025, lead researcher.