XU xingang

XU Xingang

Ph.D., Associate Professor , Doctoral Advisor

Born in May 1974, China.

Contact

Address: College of Veterinary Medicine, Northwest A&F University

No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.

Email: 286567031@qq.com

Mobile: +86 13468811854

1. Education and Work Experience

2005– now, Associate Professor, College of Veterinary Medicine, Northwest A&F University.

2013– 2014, Visiting Scholar, College of Veterinary Medicine, University of Georgia, USA.

2006– 2007, Postdoctoral, College of Veterinary Medicine, Pingtung University of Science and Technology, Taiwan

2001– 2005, Ph.D, Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University.

1997– 2000, M.S, Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University.

1992– 1997, B.A, Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University.

2. Research and Teaching

Research interests:

Molecular Etiology and Immunology

Epizootiology

Teaching:

Undergraduate: Veterinary Microbiology, Veterinary Microbiology Experiment, Aquatic Animal Microbiology, Animal Microbiology Experiment Technology et al.

Master Degree: Veterinary Etiology.

Doctoral Candidate: Veterinary Molecular Microbiology, New Technology of Veterinary Diagnosis and Treatment.

3. Memberships and Academic Services

Member of China Animal Husbandry and Veterinary Medical Association, Member of National Bacterial Disease Prevention and Control Team of Chorionic Sheep, Science and Technology Commissioner of Shaanxi Province.

Talents from "Three Regions" of Shaanxi Province, and Communication Review Experts of Dissertations of Ministry of Education.

Youth Committee Member of Veterinary Microbiology Professional Committee of Chinese Society of Microbiology, Member of Chinese Society of Immunology, Member of Chinese Society of Microbiology, Editorial Board Member of Progress in Animal Medicine.

Invited reviewers of SCI journals such as  Vaccine ,  Veterinary Microbiology ,  Journal of Virological Methods ,  Acta   Virologica , and  Virology Journal .

Expert in reviewing manuscripts of  Journal of Animal Husbandry and Veterinary Medicine ,  Chinese Journal of Agricultural Sciences ,  Journal of Northwest A & F University (Natural Science Edition),  Chinese Veterinary Sciences.

4. Honors and Awards

In November 2020, he was rated as an advanced individual in the work of scientific and technological talents in the "Third District" of Ankang City by the Science and Technology Bureau of Ankang City.

Special Prize for the 6th National College Student Animal Medicine Professional Skills Contest (Shengtaier Cup) in 2020, Instructor.

Special Prize of the 5th National College Student Animal Medicine Professional Skills Contest (Shengtaier Cup) in 2018, Instructor.

Special Prize of the 4th National College Student Animal Medicine Professional Skills Contest (Shengtaier Cup) in 2016, Instructor.

First Prize of Excellent Academic Report of College of Veterinary Medicine in 2009.

The Excellent Teacher, College of Veterinary Medicine in 2009.

First Prize of Young Teachers' Lecture Competition in 2006 College of Animal Science and Technology.

"Study on Comprehensive Control Technology of Infectious Bursal Disease in Chickens" won the first prize of "Scientific and Technological Progress Award of Shaanxi Province" of Shaanxi Provincial People's Government in 2001.

"Study on comprehensive control technology of infectious bursal disease in chickens" won the first prize of "Scientific and Technological Progress of Agriculture and Animal Husbandry in Shaanxi Province" by Shaanxi Provincial Department of Agriculture in 2000.

5. Publications

[1] Zhang Q, Yang F, Gao J, Zhang W, Xu X(corresponding author). Development of multiplex TaqMan qPCR for simultaneous detection and differentiation of eight common swine viral and bacterial pathogens.  Braz J Microbiol , 2021 Oct 28.

[2] Mingzhe Fu,Yuchao Yan, Hong Su, Jingjing Wang, Xiaojie Shi, Hongchao Zhou, Qi Zhang , Xingang Xu(corresponding author). Spleen proteome profiling of dairy goats infected with C. pseudotuberculosis by TMT-based quantitative proteomics approach.  Journal of Proteomics , 2021, 248:104352.

[3]Pei Sun , Jian Jin, Lixiang Wang , Jingjing Wang , Hongchao Zhou , Qi Zhang , Xingang Xu(corresponding author). Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways. Veterinary Microbiology , 2021 ,253:108959.

[4] Mingzhe Fu, Hong Su, Zhanqiang Su , Zheng Yin, Jian Jin , Lixiang Wang , Qi Zhang , Xingang Xu(corresponding author). Transcriptome analysis of Corynebacterium pseudotuberculosis-infected spleen of dairy goats.  Microbial Pathogenesis , 2020 (147) 104370.）

[5] Xingang Xu(the first author), YingXu, Qi Zhang, FengYang, ZhengYin, Lixiang Wang, QinfanLi. Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways.  Veterinary Microbiology , 2019, 232:1-12.

[6] Xingang Xu(the first author), Feng Yang, Qi Zhang, Ying Xu, Jiali Huang, Mingzhe Fu, Weimin Zhang.Development of a multiplex TaqMan qPCR assay for simultaneous detection and differentiation of four DNA and RNA viruses from clinical samples of sheep and goats.  Journal of Viroloical Methods , 2019,266 : 58-64.

[7] Pei Sun, Qarih Fahd, Yezhen Li, Yao Sun, Jie Li, Majjid A. Qaria, Zhan Song He, Yuzhen Fan, Qiang Zhang, Qianming Xu, Zongjun Yin, Xingang Xu(corresponding author), Yu Li. Transcriptomic analysis of small intestinal mucosa from porcine epidemic diarrhea virus infected piglets .  Microbial Pathogenesis , 2019,132:73-79 .

[8] Hongqing Zheng , Lei Xu , Yuzhong Liu, Cheng Li , Liang Zhang, Tao Wang , Di Zhao , Xingang Xu(corresponding author), Yanming Zhang. MicroRNA-221-5p Inhibits Porcine Epidemic Diarrhea Virus Replication by Targeting Genomic Viral RNA and Activating the NF-κB Pathway.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ( Int. J. Mol. Sci. ), 2018, 19, 3381.

[9] Pei Sun, Haoyang Wu, Jiali Huang, Ying Xu, Feng Yang, Qi Zhang, Xingang Xu(corresponding author). Porcine epidemic diarrhea virus through p53-dependent pathway causes cell cycle arrest in the G0/G1 phase,  Virus Research , 2018 (253) 1-11.

[10] Qi Zhang, Ying Xu, Rong Chang, Dewen Tong，Xingang Xu(corresponding author). Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell.  Research in Veterinary Science , 2018, 2018 (119) 109-115.

[11] Q. ZHANG, J. L. HUANG, Y. B. LIANG,Y. P. HE, D. W TONG, X. G. XU(corresponding author). Transmissible gastroenteritis virus nsp7 protein localized in down-regulates interleukin 8 expression in porcine intestinal the cytoplasm epithelial cell.  Acta virologica .2018, 62: 41-49.

[12] Ya-Peng He, Qi Zhang, Ming-Zhe Fu, Xin-Gang Xu(corresponding author). Development of multiplex PCR for simultaneous detection and differentiation of six DNA and RNA viruses from clinical samples of sheep and goats.  Journal of   Virological Methods , 2017, 243:44-49.

[13] Yapeng He, Qi Zhang, Jing Wang, Man Zhou, Mingzhe Fu, Xingang Xu(corresponding author). Full-length genome sequence analysis of enzootic nasal tumor virus isolated from goats in China.  Virology Journal , 2017, 14:141.

[14] Xuefeng Qi, Caihong Liu, Ruiqiao Li, Huizhu Zhang, Xingang Xu*(corresponding author), Jingyu Wang. Modulation of the innate immune-related genes expression in H9N2 avian influenza virus-infected chicken macrophage-like cells (HD11)in response to Escherichia coli LPS stimulation.  Research in Veterinary Science , 2017 (111) 36-42.

[15] Yu-Xin Gong, Bin Zhu, Guang-Lu Liu, Lei Liu, Fei Ling, Gao-Xue Wang, Xin-Gang Xu*(corresponding author). Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effects of a recombinant vaccine against Aeromonas hydrophila.  Fish and Shellfish Immunology , 2015, 42（1）: 213- 220.

[16] Wang J, Tang C, Wang Q, Li R, Chen Z, Han X, Wang J, Xu X*(corresponding author). Apoptosis induction and release of inflammatory cytokines in the oviduct of egg-laying hens experimentally infected with H9N2 avian influenza virus.  Vet Microbiol , 2015, 12;177(3-4):302-314.

[17] Xu X(the first author), Zhang H, Zhang Q, Rong C, Huang Y, Tong D. Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and subcellular localization in the porcine intestinal epithelial cell.  Acta virologica , 2015,59（3）: 265-275.

[18] Xu X(the first author), Zhang H, Zhang Q, Huang Y, Dong J, Liang Y, Liu HJ, Tong D. Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression.  Vet Microbiol , 2013, 164(3-4):212-21.

[19] Xu X(the first author), Zhang H, Zhang Q, Dong J, Liang Y, Huang Y, Liu HJ, Tong D. Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression.  Virol J , 2013, 19; 10:26.

[20] Xin-Gang Xu(the first author), Zhi-Sheng Wang, Qi Zhang, Zhao-Cai Li, Li Ding, Wei Li, Hung-Yi Wu, Ching-Dong Chang, Long-Huw Lee, De-Wen Tong, Hung-Jen Liu . Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: Baculovirus virions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2.  Journal of Virological Methods , 2012,179(2), 359-366.

[21] Xin-Gang Xu(the first author), Hong-Ni Zhao, Qi Zhang, Li Ding, Zhao-Cai Li, Wei Li, De-Wen Tong*, Hung-Jen Liu*. Oral vaccination with attenuated Salmonella enterica serovar Typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models.  Veterinary Microbiology , 2012, 157(3-4):294-303.

[22] Xin-Gang Xu(the first author), Guang-Da Chen , Yong Huang, Li Ding , Zhao-Cai Li, Ching-Dong Chang, De-Wen Tong* , Hung-Jen Liu*. Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses.  Journal of Virological Methods , 2012, 183(1):69-74.

[23] Xu X(the first author), Zhang K, Huang Y, Ding L, Chen G, Zhang H, Tong D. Bovine herpes virus type 1 induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells. Virology Journal , 2012, 17;9: 202.

[24] Zhao-Cai Li, Xin-Gang Xu(Joint first author). Yong Huang , Li Ding, Zhi-Sheng Wang ,Gao-Shui Yu, Dan Xu, Wei Li, Dewen Tong*. Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts.  International Journal of Biological Sciences , 2012; 8(3):394-405.

[25] Li Ding, Xin-Gang Xu (Joint first author), Yong Huang , Zhao-Cai Li, Zhi-Sheng Wang ,Gao-Shui Yu, Dan Xu, Wei Li, Dewen Tong*. Transmissible gastroenteritis virus induces apoptosis through FasL and mitochondrion-mediated pathway dependent of viral replication.  Veterinary Microbiology , 2012, 158(1-2):12-22.

[26] Xin-Gang Xu(the first author), Zhi-Sheng Wang, Qi Zhang, Zhao-Cai Li, Hong-Ni Zhao, Wei Li, De-Wen Tong, Hung-Jen Liu. Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models.  Vaccine , 2011, 29(4):636-643.

[27] Xin-Gang Xu(the first author), Zhi-Sheng Wang, Qi Zhang, Zhao-Cai Li, Kuan Zhang, Wei Li, De-Wen Tong , Hung-Jen Liu. Baculovirus virions displaying infectious bursal disease virus VP2 protein protect chickens against infectious bursal disease virus infection.  Avian Diseases , 2011，55: 223–229.

[28] Zhi-sheng Wang, Xin-gang Xu(Joint first author), Hung-jen Liu, Zhao-cai Li1, Li Ding, Gao-shui Yu1, Dan Xu and Dewen Tong. Immunogenicity of envelope GP5 protein displayed on baculovirus and protective efficacy against virulent porcine reproductive and respiratory syndrome virus challenge in piglets.  African Journal of Microbiology Research , 2011, 5(18): 2682-2691.

[29] ZS WANG, XG XU(Joint first author), H.J LIU, ZC LI, L. DING, G.S YU, DW TONG1. Immunogenicity of envelope GP3 protein of porcine reproductive and respiratory syndrome virus displayed on baculovirus.  Acta virologica , 2011, 55:139 -146.

[30] Xin-Gang Xu(the first author), De-Wen Tong, Ming-Tang Chiou, Yao-Ching Hsieh, Wen-Ling Shih, Ching-Dong Chang, Ming-Huei Liao, Yan-Ming Zhang, Hung-Jen Liu. Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus.  Journal of Virological Methods , 2009, (159)2: 259-264.

[31] Xin-Gang Xu(the first author), Ming-Tang Chiou, Yan-Ming Zhang, De-Wen Tong, Jian-He Hu, Miao-Tao Zhang, Hung-Jen Liu. Baculovirus surface display of Erns envelope glycoprotein of classical swine fever virus.  Journal of Virological Methods , 2008, 153(2): 149-155.

[32] Xin-Gang Xu(the first author), Hung-Jen Liu. Baculovirus surface display of E2 envelope glycoprotein of classical swine fever virus and immunogenicity of the displayed proteins in a mouse model.  Vaccine , 2008, 26(43): 5455-5460.

6. Projects and Funding

[1] Project Title, Research on the integration of perinatal disease prevention and control technology of Dairy sheep, Jinchang Science and Technology Discovery Project in 2021 (202100-001), 2021-2023.

[2] Project Title, Establishment and application of multiplex real-time fluorescent quantitative TaqMan PCR for detection of multiple common pathogens in dairy goats. Shaanxi Key Research and Development Program (2021NY-024), 2021-2022.

[3] Project Title, Integration and demonstration promotion of rapid disease detection technology in large-scale dairy goat farms, Science and Technology Innovation and Achievement Transformation Project of Northwest A&F University Experimental Demonstration Station (Base) in 2020 (TGZX2020-12) 2020-2021.

[4] Project Title, Integration and demonstration of key technologies for disease prevention and control in large-scale sheep farms, Science and Technology Innovation Drive Project of Shaanxi Agricultural Department (NYKJ-2018-YL02), 2018-2020.

[5] Project Title, Research and demonstration of key technologies for comprehensive prevention and control of porcine epidemic diarrhea, Xi 'an Agricultural Science and Technology Innovation Program (2017050NC/NY010), 2017.1-2019.12.

[6] Project Title, Research and promotion of visual LAMP rapid detection of sheep common pathogen infection, 2017 Science and Technology Achievement Promotion Project of Northwest A&F University Experiment Demonstration Station (Base), 2017.6-2019.5.

[7] Project Title, Key Technology research and Demonstration of Major disease prevention and control in dairy goats, Shaanxi Science and Technology Department Industry Chain Project, 2016KTZDNY02-06, 2016.1-2018.12.

[8] Project Title, Integration and demonstration promotion of major disease prevention and control technology in large-scale mutton sheep farms, Agricultural Science and Technology demonstration and promotion capacity improvement project in Yangling Demonstration Zone (TS-2016-13), 2016.1-2017.12.

[9] Project Title, Research and demonstration of multiplex PCR rapid detection method for seven sheep virus infection, Shaanxi Agricultural Science and Technology Innovation and Key Research Project, 2016NY-092, 2016.1-2017.12.