武春燕
1. 个人基本信息
武春燕,女,1985年2月出生,甘肃兰州人,德国慕尼黑大学免疫学博士,美国马里兰大学博士后。 2015年9月以“青年英才计划”高层次人才引进的方式入职永乐高ylg888888,现任副教授(专业技术5级岗),博士生导师。目前主要从事猪繁殖与呼吸道综合征病毒(PRRSV),非洲猪瘟病毒(ASFV)致病机制及新型防控产品研发,累计发表SCI论文30余篇,其中第一作者及通讯作者论文20余篇。累计主持国家自然基金面上项目,陕西省自然科学基金,陕西省引进人才专项,校级引进人才科研启动经费及企业横向产业化课题10余项。
2. 教育及工作经历
2003年-2009年: 西北农林科技大学生物工程基地班本硕连读
2009年-2014年: 德国慕尼黑大学免疫学博士;
2014年-2015年: 美国马里兰大学, 分子病毒学方向, 博士后;
2015年9月至今: 永乐高ylg888888,副教授;
3. 研究方向
(1)PRRSV及ASFV与宿主细胞相互作用及对宿主致病机制研究;
(2)治疗性PRRSV广谱中和抗体研发和应用;
(3)基于“免疫肽组库”技术的新型疫苗研发平台的建立及其在猪重大病毒疫苗中的应用;
4. 主讲课程
本科生:《免疫生物学》(全英文课程,双语课程);《免疫学》(全英文课程),硕士生《兽医免疫学》;
5. 在研科研项目
(1)国家自然科学基金面上项目(2022年-2025年):非洲猪瘟病毒抑制树突状细胞SLA-DR介导的抗原提呈功能及逃逸宿主获得性免疫应答的机制,59万;主持;
(2)金宇保灵生物药品有限公司横向课题:非洲猪瘟病毒亚单位疫苗研发;300万;主持;
(3)广东永顺生物制药股份有限公司横向课题:非洲猪瘟基亚单位疫苗研发一期:300万;主持;
(4)中牧实业股份有限公司横向课题:基于免疫肽组库分析技术的猪口蹄疫免疫肽疫苗研究;30万;主持;
(5)新疆方牧生物有限公司抗体产业化课题:150万;主持
6. 已结题科研项目
(1)西北农林科技大学引进人才科研启动经费:60万;主持;
(2)陕西省人才专项经费:20万;主持;
(3)陕西省自然科学基金:5万;主持;
(4)陕西省2021年度农业专项资金(2021-2022): 10万;主持
7. 代表性论文
2022年
[1]. Qi Ji, Guanggang Qu, Bing Liu, Yang Bai, Guihua Wang, Rui Chen, Xu Zheng, Zhigang Zhang, Yonglin Yang and Chunyan Wu* . Evaluation of porcine GM-CSF during PRRSV infection in vitro and in vivo indicating a protective role of GM-CSF related with M1 biased activation in alveolar macrophage during PRRSV infection;Frontiers in Immunology,(中科院2区,Top期刊) 2021, (影响因子:8.786,通讯作者)
2021年
[1].Zhigang Zhang, Tianshu Zhai, Mingshuo Li, Kun Zhang, Jingrui Li, Xu Zheng, Chaonan Tian, Rui Chen, Jianhui Dong, En-Min Zhou*, Yuchen Nan* and Chunyan Wu * ; A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets, Veterinary Research, (中科院2区,Top期刊) 2021, (影响因子:3.683,通讯作者)
[2].Chengbo Zhu, Jingrui Li, Chaonan Tian, Mengmeng Qin, Zhenni Wang, Bingjun Shi, Guanggang Qu*, Chunyan Wu* and Yuchen Nan*; Proteomic Analysis of ISGylation in Immortalized Porcine Alveolar Macrophage Cell Lines Induced by Type I Interferon, Vaccines, (中科院2区) 2021, (影响因子:4.422,通讯作者)
[3].Xiaohui Ju#, Fang Li#, Jingrui Li#, Chunyan Wu# , Guangtao Xiang Xiaomin Zhao, Yuchen Nan*, Dongming Zhao * and Qiang Ding * ; Genome-wide transcriptomic analysis of highly virulent African swine fever virus infection reveals complex and unique virus host interaction, Veterinary Microbiology, (中科院2区,Top期刊) 2021, (影响因子:3.293,共同第一作者);
[4]. Jie Wang, Yajing Wang, Bing Liu, Yunwei He, Zhiwei Li, Qin Zhao, Yuchen Nan* and Chunyan Wu *; Porcine epidemic diarrhea Virus envelope protein blocks SLA-DR expression in barrow-derived dendritic cells by inhibiting promoters activation, Frontiers in Immunology, (中科院2区,Top期刊) 2021, (影响因子:7.561,通讯作者);
2020年
[1]. Chunyan Wu ; Guoqian Gu, Tianshu Zhai, Yajing Wang Yongling Yang, Yafei Li, Xu Zheng, Qin Zhao; En-Min Zhou * and Yuchen Nan * and Broad neutralization activity against both PRRSV-1 and PRRSV-2 and enhancement of cell mediated immunity against PRRSV by a novel IgM monoclonal antibody, Antiviral Research (中科院2区) , 2020, (影响因子:5.970)
[2] .Chunyan Wu, Bingjun Shi, Di Yang, Kun Zhang, Jie Li, Jie Wang, Hongliang Liu, Qin Zhao, En-Min Zhou* and Yuchen Nan*; Porcine Reproductive and Respiratory Syndrome Virus promotes SLA-DR-mediated antigen presentation of non-structure proteins to evoke a non-neutralizing antibody response in vivo , Journal of Virology, (双一流G2类) 2020, (影响因子:5.103)
[3].Yafei Li, Junhui Li, Sun He, Wei Zhang, Jian Cao, Xiaomei Pan, Huifen Tang, En-Min Zhou *, Chunyan Wu* and Yuchen Nan*; Interferon Inducing Porcine Reproductive and Respiratory Syndrome Virus Vaccine Candidate Protected Piglets from HP-PRRSV Challenge and Evoke a Higher Level of Neutralizing Antibodies Response, Vaccines, (中科院2区)2020, (影响因子:4.422,通讯作者)
[4].Liangliang Li, Lu Zhang, Qifan Hu, Liang Zhao, Yuchen Nan, Gaopeng Hou, Yiyang Chen, Ximeng Han, Xiaolei Ren, Qin Zhao, Hu Tao, Zhenzhao Sun, Gaiping Zhang, Chunyan Wu*, Jingfei Wang*, En-Min Zhou* : MYH9 Key Amino Acid Residues Identified by the Anti-Idiotypic Antibody to Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 5 Involve in the Virus Internalization by Porcine Alveolar Macrophages, Viruses ( 中科院2区) , 2020, (影响因子:5.048,通讯作者)
2019年
[1].Lizhen Wang, Lu Zhang, Baichen Huang, Kuokuo Li, Gaopeng Hou, Qin Zhao, Chunyan Wu , Yuchen Nan , Taofeng Du, Yang Mu, Jixun Lan, Hongying Chen and En-Min Zhoua*; A Nanobody Targeting Viral Non-Structural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication, Journal of Virology (双一流G2类) , 2019, (影响因子:5.103)
[2].Gaopeng Hou, Biyun Xue, Liangliang Li, Yuchen Nan, Lu Zhang, Kuokuo Li, Qin Zhao, Julian Hiscox, James Stewart, Chunyan Wu *, Jingfei Wang* and En-Min Zhou*; Direct interaction between CD163 N-terminal domain and MYH9 C-terminal domain contributes to porcine reproductive and respiratory syndrome virus internalization by permissive cells, Frontiers in Microbiology (中科院2区,Top期刊) , 2019, (影响因子:5.646,通讯作者)
[3].Jie Wang, Jie Li, Nana Wang, Qi Ji, Mingshuo Li, Yuchen Nan, En-Min Zhou, Yanjin Zhang and Chunyan Wu *; The 40 kDa Linear Polyethylenimine Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection by Blocking Its Attachment to Permissive Cells, Viruses (中科院2区) , 2019, (影响因子:5.048,通讯作者)
[4].Biyun Xue, Gaopeng Hou, Guixi Zhang, Jingjing Huang, Liangliang Li, Yuchen Nan, Yang Mu, Lizhen Wang, Lu Zhang, Ximeng Han, Xiaolei Ren, Qin Zhao, Chunyan Wu* , Jingfei Wang * and En-Min Zhou * ; MYH9 1 Aggregation Induced by Direct Interaction with PRRSV GP5 Ectodomain Facilitates Viral Internalization by Permissive Cells, Frontiers in Microbiology ( 中科院2区,Top期刊) , 2019, (影响因子:5.646,通讯作者)
2018年
[1].Yuchen Nan; Chunyan Wu* ; and Yan-Jin Zhang * ; Interferon Independent Non‐Canonical STAT
Activation and Virus Induced Inflammation, Viruses ( 中科院2区) , 2018, (影响因子:5.048,通讯作者)
[2].Liangliang Li; Biyun Xu; Weiyao Sun; Guoqian Gu; Gaopeng Hou; Lu Zhang; Chunyan Wu ; Qin Zhao; Yanjin Zhang; Gaiping Zhang; Julian A. Hiscox; Yuchen Nan * and En-Min Zhou * ; Recombinant MYH9 protein C-terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5, Antiviral Research ( 中科院2区) , 2018, (影响因子:5.970)
[3].Jie Li, Gang Wang, Di Yang, Bao Zhao, Yongpan Zhao, Yonggang Liu, Xuehui Cai, Yuchen Nan, En-Min Zhou* and Chunyan Wu , * ; Development of luciferase-linked antibody capture assay based on luciferase Immunoprecipitation systems for antibody detection of porcine reproductive and respiratory syndrome virus, BMC Biotechnology ( 中科院3区) , 2018, (影响因子:2.7,通讯作者)
2017年
[1]. Yuchen Nan* Chunyan Wu * , Guoqian Gu, Weirao Sun and En-Min Zhou; Improved Vaccine against PRRSV: Current progress and future perspective, Frontiers in Microbiology ( 中科院2区,Top期刊), 2016, (影响因子:5.646,共同第一作者)
[2].Yuchen Nan, Chunyan Wu , Qin Zhao and En-Min Zhou*; Zoonotic Hepatitis E Virus: An Ignored Risk for Public Health; Frontiers in Microbiology ( 中科院2区,Top期刊), 2016, (影响因子:5.646,共同第一作者)
[3].Yuchen Nan, Chunyan Wu * and Yan-Jin Zhang*;Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism; Frontiers in Immunology ( 中科院2区,Top期刊), 2016, (影响因子:7.561,通讯作者)
2015年
[1]. Chunyan Wu , Yuchen Nan and Yan-Jin Zhang;New insights into virus–cell interactions during HEV infection: The double roles of HEV in IFNs induction (邀稿文章). Future Virology; 2015;10(4): 439-448 (共同第一作者) (影响因子:1.0)
2013年
[1]. C hunyan , Wu ., M, Aichinger., J, Nedjic. and L, Klein. Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance. Autophagy (双一流G2类,中科院1区,Top期刊);2013; 9(6):931-2. (IF="12.042)" ;(影响因子:12.042)
[2]. M, Aichinger.*, C hunyan , Wu .*, J, Nedjic. and L, Klein. Macroautophagy substrates are loaded onto MHC Class II of medullary thymic epithelial cells for central tolerance. J. Exp. Med(双一流G1类). 2013; 210 (2):287-300. (* Co-first author) (影响因子:13.912,共同第一作者)
7.联系方式
陕西省咸阳市杨凌区西农路22号永乐高ylg8888884253号
邮件:chunyanwu@nwsuaf.edu.cn;