杨藩
一、基本信息
杨藩,男,汉族,籍贯四川绵阳市,中共党员,理学博士,青年教授,博士生导师。
二、教育及工作经历
教育经历:
2008.09 – 2012.06, 西北农林科技大学,动物科学专业毕业,农学学士(创新基地班,第四年开进入研究生阶段)
2012.09 – 2017.12, 西北农林科技大学,生理学专业毕业,理学博士 (猪多能性细胞维持分子机理研究,合作导师王华岩)
2015.10 – 2017.12, 美国西奈山医学院,干细胞与发育平台,联合培养博士 (小鼠全能性能细胞转化机制研究,合作导师Jianlong Wang)
工作经历:
2017年 12月至 2018 年 6月,在西奈山医学院从事全职博士后科研工作 (小鼠心脏发育相关基因研究,合作导师ChenlengCai)
2018年 6 月至 2020年 10月,在印第安纳大学医学院从事全职博士后科研工作 (小鼠心脏发育相关基因研究,合作导师ChenlengCai)
2021年 1 月至今,在永乐高ylg888888基础兽医系从事教学科研工作,教授。
三、研究方向及开设课程
目前开展小鼠多能性干细胞向全能性细胞转化及心脏流出道发育调控相关研究。
本科生《细胞生物学》或《生理学》课程和研究生《干细胞与组织工程》《动物生物技术专题》课程
四、代表性学术成果
发表论文:
1、代表性论文
(1) Fan Yang, Xin Huang, RugeZang, Jiayu Chen, Miguel Fidalgo, Carlos Sanchez-Priego, JihongYang, Alexander Caichen, Fanglin Ma, Todd Macfarlan, Huayan Wang, ShaorongGao*, Hongwei Zhou,Jianlong Wang*, DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell stem Cell, 2020, 26(2): 234–250
(2) Fan Yang, YahuiRen, Huan Li, Huayan Wang*, ESRRB plays a crucial role in the promotion ofporcine cell reprogramming. Journal of cellular physiology, 2018; 233:1601–1611
(3) Fan Yang, Ning Wang, Yaxian Wang, Tong Yu, Huayan Wang*. Activin‐SMAD signaling isrequired for maintenance of porcine ips cell self‐renewal through upregulation of nanog and oct4 expression.Journal of cellular physiology, 2017. 232(8): p. 2253-2262
(4) Fan Yang, Xiaomin Du, Yaxian Wang, Chuanzhen Wang, Changcai Huang, Qundeng Xiao, XueBai,Huayan Wang*. Characterization and functional analysis of porcine estrogen-related receptors and theiralternative splicing variants. Journal of Animal Science, 2015, 93(9):4258-66
(5) Fan Yang, Jinglong Zhang, Yajun Liu, De Cheng, Huayan Wang*. Structure and functionalevaluation of porcine NANOG that is a single-exon gene and has two pseudogenes. The international journal of biochemistry & cell biology, 2015, 59: 142–152
2、论著之外的代表性研究成果和学术奖励(合计 10项以内)。
(1) Fan Yang, Ning Wang, Yajun Liu, Huayan Wang*. Identification and functional analysis of porcine basic helix-loop-helix transcriptional factor 3 (TCF3) and their alternative splicing isoforms. Res. Vet. Sci,2016,105:1-4
(2) 杨藩, 王亚娴,杜丽霞,王华岩. 猪 ESRRB 启动子克隆及其调控活性检测. 生物工程学报,2015, 31.004: 491-500.
(3) 杨藩, 王宁, 徐西占, 司玮, 王苗, 王华岩. 转 lux 基因簇大肠杆菌在小鼠肠道内定植模型的建立.农业生物技术学报, 2014, 22.8: 925-932.
(4) 王亚娴, 杨藩(共同一作), 王华岩. Sall4 表达调控及其启动子核心调控区的筛选. 中国农业科学,2016, 49.1: 176-185.
(5) Donghua Hu, Lu Zhang, Fan Yang, Fuxue Chen, Deqiang Li, Chen-LengCai. Generation of Pecam1 endothelial specific dual reporter mouse model. genesis, 2020, 58.9: e23384.
(6) JianRuan, Lu Zhang, Donghua Hu, XianghuQu, Fan Yang, Fuxue Chen, Xiangqin He, JianShen,Kunzhe Dong, Megan Sweet, Christina Sanchez, Deqiang Li, WeinianShou, Jiliang Zhou*, Chen-LengCai*.Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells.Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ATVBAHA. 120.315107.
(7) Lu Zhang, Nishat Sultana, Jianyun Yan, Fan Yang, Fuxue Chen, Elena Chepurko, Feng-Chun Yang,Qinghua Du, LiorZangi, MingjiangXu, Lei Bu, Chen-LengCai*, Cardiac Sca-1+ Cells Are Not Intrinsic,Stem Cells for Myocardial Development, Renewal, and Repair. Circulation, 2018, 138(25): 2919-2930.
(8) Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei,Zhou, Francesco Faiola, Junjun Ding,PhensineeHaruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego,Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, MingjiangXu, Miguel Fidalgo, XiaohuaShen, Jianlong Wang*, RNA-dependent chromatin,targeting of TET2 for endogenous retrovirus control in pluripotent stem cells, Nature genetics, 2018, 50(3):443–451.
(9) Xin Huang, Sophie Balmer, Fan Yang, Miguel Fidalgo, Dan Li, Diana Guallar, Anna- Katerina Hadjantonakis*, Jianlong Wang*, Zfp281 is essential for epiblast maturation through transcriptional control of Nodal Signaling in the mouse embryo.Elife, 6 (2017): e33333.
(10) Saunders, A., D. Li, F. Faiola, X. Huang, M. Fidalgo, D. Guallar, J. Ding, F. Yang, Y. Xu, H. Zhou,J. Wang*. Context-dependent functions of nanog phosphorylation in pluripotency and reprogramming. Stem Cell Reports, 2017. 8(5): p. 1115-1123.
五、科研项目
西北农林科技大学引进人才科研启动经费:100万;主持
六、获奖情况
2015/12:博士研究生国家奖学金
七、联系方式
通讯地址:陕西杨凌邰城路 3号西北农林科技大学南校区科研楼 2303B办公室
邮编: 712100
电子邮箱: fan.yang@nwafu.edu.cn
联系电话:029-87080069